Despite the prepdominat agent causing severe entero-pathogenic diarrhea in swine, there
are no effective therapeutical treatment of porcine epidemic diarrhea virus (PEDV). In this
study, we evaluated the antiviral activity of five phlorotannins isolated from Ecklonia cava (E.
cava) against PEDV. In vitro antiviral activity was tested using two different assay
strategies:(1) blockage of the binding of virus to cells (simultaneous-treatment assay) and (2)
inhibition of viral replication (post-treatment assay). In simultaneous-treatment assay …